What Are the Effects of Ketamine on People With PTSD?

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Are you experiencing a horrific past event again? Have you tried therapies but not been able to get better? If so, ketamine may be an excellent option for you. But how does ketamine on people with PTSD really work?

At Anti Aging and Ketamine Center, our certified healthcare professionals offer innovative ketamine treatment to help those suffering from PTSD find comfort and relief. To help you better understand what are the effects of ketamine on people with PTSD, our healthcare experts share valuable insights and knowledge on the eligibility of ketamine treatment for PTSD.

Does Ketamine on People with PTSD Really Work?

Ketamine, primarily known as an anesthetic and recreational drug, shows promise in alleviating symptoms of PTSD. Research suggests that ketamine, when administered in controlled doses, can rapidly reduce PTSD symptoms, including intrusive thoughts and nightmares. 

Even though ketamine treatment for PTSD is still a relatively new option, a study supported by the VA Office of Research and Development found that most veteran patients with treatment-resistant PTSD experienced symptom relief after receiving two ketamine treatments per week via infusion for four weeks.

However, long-term efficacy and safety are still under investigation, with concerns about potential abuse and side effects. Nonetheless, ketamine represents a potential breakthrough in PTSD treatment, offering hope for those who struggle with the debilitating disorder.

Effects of Ketamine on People with PTSD

A common symptom of post-traumatic stress disorder or PTSD that can plague and hinder individuals is intrusive memories of trauma. Ketamine’s effects on individuals with PTSD can vary but often include rapid reduction of symptoms such as intrusive thoughts, flashbacks, and nightmares. 

Unlike traditional treatments, which often take weeks to show effects, ketamine’s action is swift. It targets the brain’s glutamate system. By blocking N-methyl-D-aspartate (NMDA) receptors, ketamine may disrupt the consolidation of traumatic memories. 

Here are the potential effects of ketamine on people with PTSD:

Rapid reduction of symptoms

Ketamine has been observed to rapidly alleviate symptoms of PTSD, such as intrusive thoughts, flashbacks, and nightmares, often within hours of administration.

Dissociative effects

Ketamine can induce a dissociative state, where individuals feel detached from their surroundings and sense of self. This altered state of consciousness may facilitate the processing of traumatic memories and emotions.

Improved mood

Ketamine has been shown to have rapid-acting antidepressant effects in individuals with PTSD, leading to improvements in mood and overall well-being.

Enhanced therapeutic response

Some studies suggest that ketamine may enhance the effectiveness of traditional psychotherapy by helping individuals engage more deeply in therapeutic processes and facilitating emotional exploration.

Potential for long-term relief

While the duration of ketamine’s effects varies among individuals, some research indicates that repeated administrations of ketamine may lead to longer-lasting relief from PTSD symptoms, particularly when combined with ongoing therapy and support.

Improvement in sleep disturbances

Ketamine administration has been associated with improvements in sleep quality among individuals with PTSD, including reductions in insomnia and nightmares, leading to better overall sleep patterns.

Increased resilience

Some research suggests that ketamine treatment may enhance resilience to stress and trauma by promoting neuroplasticity and facilitating the formation of adaptive coping mechanisms, potentially reducing the risk of future PTSD symptoms following exposure to new traumatic events.

Eligibility of Ketamine on People with PTSD

If you are experiencing the impact that PTSD can have on your quality of life, there are a variety of alternative therapies available, and ketamine might be one that helps you. Ketamine has historically been used as an anesthetic for people who need quick treatments. It usually doesn’t cause many problems or adverse effects, wears off fast, and works effectively. 

To obtain eligibility for ketamine on people with PTSD, here’s what you should know:

Diagnosis of PTSD

Individuals must have a confirmed diagnosis of post-traumatic stress disorder (PTSD) by a qualified mental health professional based on clinical evaluation and standardized diagnostic criteria.

Treatment resistance

Ketamine treatment for PTSD is often considered for individuals who have not responded adequately to conventional treatments such as antidepressant medications and psychotherapy or who have experienced only partial symptom relief.

Severity of symptoms

Ketamine may be considered for individuals with moderate to severe PTSD symptoms, including intrusive thoughts, flashbacks, nightmares, hypervigilance, and mood disturbances, which significantly impair daily functioning and quality of life.

Absence of contraindications

Individuals undergoing ketamine treatment should not have contraindications that increase the risk of adverse effects, such as a history of psychosis, uncontrolled hypertension, or certain medical conditions that may interact negatively with ketamine.

Supervised administration

Ketamine treatment should be administered by trained healthcare professionals in a controlled clinical setting to ensure safety and monitor for any adverse reactions during and after the infusion.

Informed consent

Individuals and their healthcare providers should engage in thorough discussions about the potential benefits, risks, and alternatives to ketamine treatment and obtain informed consent before proceeding with the treatment plan.

Comprehensive treatment approach

Ketamine treatment for PTSD is often most effective when integrated into a comprehensive treatment plan that includes ongoing psychotherapy, medication management, and supportive care to address the complex nature of PTSD symptoms and promote long-term recovery.

Frequently Asked Questions

ketamine on people with PTSD
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What Are the Potential Side Effects of Ketamine Treatment?

Common side effects of ketamine treatment may include dissociation, nausea, increased blood pressure, and transient cognitive impairment. Long-term effects and risks, including potential for abuse and cardiovascular issues, are still being studied.

How is Ketamine Administered for Bipolar Disorder?

Ketamine for bipolar disorder treatment is typically administered intravenously (IV) or via nasal spray under medical supervision. The dosage and frequency of administration may vary depending on individual response and treatment protocol.

How Soon Can I Expect to See Results from Ketamine Treatment?

Ketamine’s rapid-acting antidepressant effects may lead to improvements in mood within hours to days following administration. However, the duration of these effects and their impact on long-term bipolar disorder management require further research.

Is Ketamine Treatment Covered by Insurance for Bipolar Disorder?

Coverage for ketamine treatment for bipolar disorder varies depending on insurance providers and specific policies. Some insurers may cover ketamine treatment for certain mental health conditions when deemed medically necessary, while others may consider it experimental and not covered. It’s essential to check with your insurance provider for coverage details and potential out-of-pocket costs.


Ketamine exhibits potential relief for bipolar disorder, providing quick alleviation of depression symptoms. But it’s important that you weigh the advantages and disadvantages of ketamine treatment carefully. 
At Anti Aging and Ketamine Center, we recognize the intricacy of bipolar disorder and the value of individualized treatment. We urge those who suffer from this mental health condition to speak with one of our qualified healthcare professionals to determine if ketamine is a good fit for them. Make an appointment now or call us to learn more about ketamine for bipolar disorder treatment.